Angiotensin-converting enzyme, bradykinin, angiotensin, and cerebral vessel reactivity.

Angiotensin-converting enzyme, bradykinin, angiotensin, and cerebral vessel reactivity.

Bradykinin (BK) produced concentration-related relaxations of cat middle cerebral arteries and was ineffective in cat basilar arteries. On rabbit basilar arteries, BK initially produced concentration-related relaxations; however, when repeated at 2-hour intervals, BK eventually produced pure contractile responses. After preincubation of the tissues with cycloheximide, BK produced reproducible r...

Angiotensin Converting Enzyme in Sarcoidosis

Angiotensin-converting enzyme, brain atrophy and cerebral small vessel disease

Background

Hydrolysis of bradykinin by angiotensin-converting enzyme.

Two dipeptides, phenylalanylarginine (Phe-Arg) and serylproline (Ser-Pro), are released sequentially from bradykinin by angiotensin-converting enzyme purified from hog lungs; chloride increases the rate of release of both dipeptides. Using an automated ninhydrin-reagent method, we studied the kinetics of bradykinin hydrolysis. The reaction proceeded in the absence of chloride; however, the addi...

Effects of converting enzyme inhibitors on angiotensin and bradykinin peptides.

We examined the dose-related effects of angiotensin-converting enzyme inhibitors on circulating and tissue levels of angiotensin and bradykinin peptides by administering perindopril or lisinopril to rats in drinking water for 7 days. A reduction in the ratio of plasma angiotensin II (Ang II) to Ang I was seen for 0.006 mg/kg per day perindopril, with an increase in plasma renin and Ang I at 0.0...